Compared with the control group, topical OVA markedly increased IgE (AD: 10.82 ± 0.0935 vs. CK: 1.937 ± 0.382), IL-4 (33.37 ± 4.417 vs. 18.15 ± 5.248); IL-1β (144.5 ± 22.27 vs. 62.31 ± 18.32); IL-10 (5.267 ± 1.424 vs. 7.13 ± 0.934); TNF-α (44.88 ± 1.486 vs. 7.114 ± 1.898); and IFN-γ (133.2 ± 17.26 vs. 47.64 ± 7.025). Here, IGHE is linked to Alzheimer disease.