INS and obesity due to melanocortin 4 receptor deficiency: According to the data obtained by calculating the percentage reduction in the area under the glycemic curve relative to the parameter of the corresponding control group (Figure 6), compounds 5a,h were found to enhance tissue insulin sensitivity to the greatest extent, with their AUC reduction values being comparable to or even exceeding the one of intact mice without obesity and type 2 diabetes (C57Bl/6J).