These include immune regulation (e.g., Portulaca oleracea L.-derived ELNs (PELNs) alleviate colitis by promoting CD4+CD8+ T cell expansion), redox balance (e.g., grapefruit ELNs eliminate reactive oxygen species), and tissue regeneration (e.g., strawberry ELNs increase fibroblast migration speed by 2.3-fold), among others [2,3]. Here, CD4 is linked to colitis.