Case 2 resulted in three out of the five analyzed tumor samples with the genetic profiles of premenopausal HER2(−)/ER(+)/PR(+), post-menopausal HER2(−)/ER(+)/PR(+) and pre-menopausal TNBC having the top ranked epitope for MHC class I as BRCA2 (Figure 7). The gene discussed is ESR1; the disease is neoplasm.