In the case of the hexane extract, it has been reported that lupenone and its synthetic derivatives can induce the death of prostate cancer cells (e.g., PC3 and DU145) by upregulating the activation of caspases 3, 8, and 9, thereby promoting apoptosis and autophagy-mediated cell death [21]. The gene discussed is CASP3; the disease is prostate carcinoma.