Similarly, it has been documented that an ethanol crude extract of the stems of E. hyemale L. and its n-hexane, dichloromethane, and ethyl acetate fractions can cause the death of oral tumor cell lines (i.e., SCC-4, SCC-9, and SCC-25) through apoptosis, chromatin condensation, activation of caspases 3/7, and DNA fragmentation. Here, CASP3 is linked to neoplasm.