Combined administration of strawberry and lemon produced the most robust therapeutic response, reducing BACE1, APP, p-Tau, and Aβ levels by 73.1%, 75.9%, 74.9%, and 69.0%, respectively, relative to the AD group, indicating a synergistic effect in mitigating amyloidogenic and tau-related pathologies. The gene discussed is BACE1; the disease is Alzheimer disease.