Strawberry and selenium, when administered individually, significantly attenuated memory impairment, oxidative stress, neuroinflammation, and apoptosis, as evidenced by marked normalization of Nrf2/HO-1, TAC, SOD, MDA, TLR4/NF-κB/TNF-α, NLRP3/CASP-1/IL-1β, and BAX/Bcl-2 signaling. Here, TLR4 is linked to memory impairment.