Notably, the combined administration of strawberry and lemon extracts elicited the most significant response, with increases of 3.4-, 3-, 2.1-, and 2.4-fold in the respective neurotransmitter levels, along with a substantial 86.4% reduction in AChE activity, indicating a synergistic restoration of the neurochemical balance in AD rats. Here, ACHE is linked to Alzheimer disease.