The combined administration of strawberry and lemon extracts produced the most profound therapeutic effect, exhibiting the greatest restoration of LRP1 expression (9.1-fold increase) and the most substantial reductions in ApoE4, NLRP3, and CASP-1 expression levels by 80.6%, 64.2%, and 74.6%, respectively, compared to the AD group, surpassing the effects of either treatment alone. The gene discussed is APOE; the disease is Alzheimer disease.