They include the inhibition of tumor suppressors through both epigenetic and post-translational mechanisms, as well as the modulation of key signaling cascades involved in cell growth and survival, notably the mitogen-activated protein kinase (MAPK), protein kinase B (AKT), and tumor protein p53 (TP53) pathways [1,48,49,50]. This evidence concerns the gene TP53 and neoplasm.