SIRT7 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, reduced SIRT7 expression—along with its association with less favorable clinical outcomes—has also been reported in hematologic malignancies such as acute and chronic myeloid leukemia (AML and CML, respectively) and B-cell acute lymphoblastic leukemia (B-ALL) [1,8,28,47].