Furthermore, in liver cancer cells, SIRT7 promotes the biosynthesis of cholesterol, fatty acids, and triglycerides through activation of the methyltransferase PRMT5, which methylates the transcription factor SREBP1a, thereby triggering a SREBP1a-dependent transcriptional program that drives the expression of lipogenic and cholesterogenic genes [76]. This evidence concerns the gene SREBF1 and liver cancer.