HLA-B*15:02 is associated with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), while HLA-A*31:01 is linked to an increased risk of drug reaction with eosinophilia and systemic symptoms (DRESS), as well as SJS/TEN induced by aromatic antiepileptic drugs [11,80]. This evidence concerns the gene HLA-B and Increased total eosinophil count.