The pathogenesis of AD is complex and involves numerous factors, such as genetics, aging, metabolism and immunity, including amyloid-β (Aβ) protein deposition, excessive phosphorylation of tau protein [4], dysfunction of cholinergic neurons [5], metal ion deposition [6], mitochondrial dysfunction, neuroinflammation and oxidative stress [7]. The gene discussed is MAPT; the disease is Alzheimer disease.