PANK1 and pantothenate kinase-associated neurodegeneration: Initially, PZ-2891 was designed as a pantothenate kinase (PANK) modulator [8,9,10], and showed great potential in the treatment of pantothenate kinase-associated neurodegeneration (PKAN) through improving the activity of PANK and the level of coenzyme A (CoA) in neurons [11].