SIRT2 and breast carcinoma: Moreover, SIRT1 and SIRT2 post-translationally regulate the activity of arylamine N-acetyltransferase 1 (NAT1), which is overexpressed in in breast cancer cells, where inhibition of SIRT1 and 2 reduced NAT1 enzymatic function, potentially impacting tumor growth, suggesting their potential as therapeutic targets [130].