For instance, hypertension may be treated by any number of drugs with any number of different mechanisms of action: for instance, (a) a calcium-channel blocker, of which several are available; (b) an angiotensin-converting enzyme inhibitor (ACE), any number of which are available; (c) an angiotensin receptor blocker, any number of which are available; (d) a thiazide diuretic, any number of which are available; and (e) an alpha receptor antagonist, any number of which are available. Here, ACE is linked to hypertensive disorder.