GOLM1 and liver cancer: In this study, a structural RNAi system was developed by using a polymerized and branched siRNA, named as GT-multi-siRNA which is a high molecular weight siRNA through connecting multiple GP73- and hTERT-targeted siRNAs to improve their stability and structural density, thereby achieving the effect of enhancing the uptake of cells and prolonging the duration of gene silence in RNAi-based gene therapy of liver cancer.