Derivative 63 exhibited a good anti-proliferative impact against FLT3-ITD positive acute myeloid leukemia (AML) cell lines, with MV4-11 IC50 = 38.8 ± 10.7 nM and MOLM-13 IC50 = 54.9 ± 4.1 nM. Here, FLT3 is linked to acute myeloid leukemia.