THBS1 and diabetes mellitus: TSP isoforms regulate connective-tissue/tendon structure and healing responses (genetic (knockout/transgenic) studies), and elevated endogenous TSP-2 (e.g., in diabetes) is associated with impaired healing, given that TSP-1/TSP-2 can drive profibrotic/anti-angiogenic/ECM-remodeling pathways that could worsen repair [325,326,327,328,329].