However, considering combining PAI-1 with increased intraocular pressure, PAI-1 contributes to glaucoma pathogenesis; the evidence includes the elevated PAI-1 in eyes with glaucoma/aqueous humor, and PAI-1 expression in anterior-segment tissues that can affect outflow; thus, the plasminogen/plasmin system (and tPA) modulates outflow/intraocular pressure [293,294,295,296]. This evidence concerns the gene SERPINE1 and glaucoma.