FGF2 and corneal ulcer: Likewise, along with reduced inflammatory cytokines (IL-6, TNF-α, MMP-2/9), increased anti-inflammatory IL-10 and antioxidant SOD-1, and improved tear production and nerve regeneration, corneal ulcer healing is consistently established with topical FGF application in several models, in animal and human studies, including topical recombinant human FGF-21, FGF-7, FGF-2, and recombinant human bFGF [198,199,200,201].