FAAH and Anxiety: Preclinical research demonstrates that inhibiting FAAH with compounds such as URB597 and PF-3845 produces robust anxiolytic and antidepressant-like effects in rodent models of chronic stress, social defeat, and anxiety [78,79,80], and newer FAAH inhibitors such as JNJ-42165279 have shown promising clinical results, including increased AEA levels and reduced activation of anxiety-related brain regions in healthy volunteers [81] as well as improved symptoms in individuals with social anxiety disorder [82].