MGLL and Anxiety: Inhibition of MAGL, the primary enzyme responsible for 2-AG degradation, also represents a valuable strategy: elevated MAGL expression is associated with heightened anxiety-like behaviors, whereas MAGL blockade enhances 2-AG signaling and reduces vulnerability to stress-induced anxiety [83,84,85], with inhibitors such as JZL184, KML29, and MJN110 consistently decreasing anxiety-like behaviors across multiple rodent paradigms [86,87,88].