GDF15 and colorectal cancer: In their report, Yamaguchi et al. [5] further confirmed the antiproliferative activity of the extracts of M. vulgare leaves in human colorectal cancer cells through the suppression of cell growth as well as the induction of apoptosis via the up-regulation of NAG-1 (the pro-apoptotic non-steroidal anti-inflammatory drug-activated gene) through the transactivation of the NAG-1 promoter.