NGF and diabetes mellitus: In streptozotocin (STZ) rats soon after diabetes induction, DRG and spinal cord show a transient up-shift in NGF pathway activity, with increased TrkA/p75 expression and kinase activation accompanying mechanical hyperalgesia; electroacupuncture delivered in this early window reduced NGF content in DRG and spinal cord, lowered TrkA phosphorylation and p75NTR in skin and improved nociceptive thresholds, consistent with the interpretation that local NGF overactivation contributes to early pain behaviors [24].