ADT-007 induced apoptosis and G2/M cell-cycle arrest in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer cell lines, while concurrently suppressing the phosphorylation of key RAS pathway effectors—cRAF (cellular rapidly accelerated fibrosarcoma kinase), MEK (mitogen-activated protein kinase kinase), AKT (protein kinase B), and ERK (extracellular signal-regulated kinase)—demonstrating broad inhibition of downstream RAS signaling [48]. The gene discussed is MAP2K7; the disease is colorectal cancer.