It has been reported that DENV activates the nuclear factor erythroid-related 2 -like 2 (NRF2) in mononuclear phagocytes through ER stress–PERK (Protein Kinase R-like ER Kinase) pathway at early stages of infection, a process attributed to the viral protease NS2B-NS3. The gene discussed is KRAS; the disease is infection.