At day 8 p.i. (i.e., the moment before IL10-KO and anti-IL-10R antibody treated mice reach their humane endpoint due to uncontrolled inflammation and severe anaemia), the mice were sacrificed, after which their organs (bone marrow and spleen) were processed into a single-cell suspension and subjected to a flow cytometric analysis to assess the RBC composition (gating strategy Figure S1). This evidence concerns the gene IL10 and anemia (phenotype).