GPC3 and congenital secretory chloride diarrhea 1: This was supported by our findings, which showed that serum GPC3 level in the HCC group was significantly higher than that in the CLD group, and its level was not correlated with the age, liver function level, number of tumors, tumor size, or presence of metastasis in HCC patients, and there was no significant difference in the GPC3 level between male and female HCC patients (p = 0.6770).