According to the results of multivariate logistic regression analysis, the early HCC diagnosis model was constructed with the following formula:GDATA = −2.031 + 0.094 × GPC3 + 0.021 × DCP + 1.692 × LN(AFP-L3%) + 0.056 × TBIL + 0.08 × AGE. The gene discussed is GPC3; the disease is hepatocellular carcinoma.