The AUCs of DCP and AFP-L3% for diagnosing HCC were 0.770 (95% CI: 0.705–0.826) and 0.683 (95% CI: 0.614–0.747) respectively, which were not statistically significant compared with GPC3 (p = 0.0790 and 0.8982) (Figure 3). Here, AFP is linked to hepatocellular carcinoma.