In addition to these global glycosylation changes, phosphorylated tau (p-tau)-containing structures such as neurofibrillary tangles (NFTs) and granulovacuolar degenerations (GVDs) have been shown to be hypersialylated in Alzheimer’s disease hippocamp, while amyloid plaque cores remain unsialylated. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.