FOXO4-DRI peptide (FOXO4-D-retro-inverso-isoform peptide) has selectively down-regulated p53-serine15 phosphorylation (p53-pS15) responsible for apoptosis resistance in keloid fibroblasts and has also promoted p53-pS15 translocation from the nucleus to the cytoplasm. The gene discussed is TP53; the disease is keloid.