PECAM1 and neoplasm: Results showed that Ki67+ tumor cells (d = 2.08; CI = 0.73–3.43) and CD31+ blood vessels (d = 1.56; CI = 0.34–2.78) were significantly lower in the tumors excised from the mice treated with ICOS-Fc-NB-PTX than in those excised from the control mice, whereas no significant effects were detected in mice treated with NB-PTX or ICOS-Fc-NB (Figure 9).