In summary, the present study suggests that OJ extract improves the symptoms of obesity-induced muscle atrophy through regulation of the PI3K-AKT-mTOR/FoxO3a signaling pathway and reprogramming of lipid metabolism in muscle tissues of mice and C2C12 myotubes (Figure 9). Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.