These results demonstrated that EBE promoted the levels of SCFA, which might suppress the activation of downstream HDAC3 and HMGB1/RAGE/NF-κB signaling pathway through their receptors GPR43, thereby reducing pro-inflammatory responses and ultimately alleviating the development of NASH caused by a high-AGEs diet. The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.