MTHFR and Lipedema: Case-control studies in Italian women with lipedema further show an over-representation of functional polymorphisms in IL-6 and in the C677T variant of MTHFR, which are associated with enhanced IL-6 production, hyperhomocysteinaemia and reduced methylation capacity, and may therefore promote endothelial dysfunction, microangiopathy and a pro-inflammatory cytokine milieu within lower-body SAT [6,7].