Likewise, in a highly controlled crossover study in women with overweight or obesity, both eTRE (08:00–16:00) and lTRE (13:00–21:00) produced no improvements in insulin sensitivity, glycemia, lipid profile, oxidative stress, or inflammatory markers under isocaloric conditions, despite excellent adherence [65]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.