Our findings also suggest that the PTPN-22 rs12730735 polymorphism may play a protective role in the development of MASLD in our cohort, and male carriers of FOXO-3 rs9400239 showed increased susceptibility, emphasizing a potential link between PTPN-22 and FOXO-3 variants and metabolic liver dysfunction in T1D. The gene discussed is FOXO3; the disease is type 1 diabetes mellitus.