GATA6 and rheumatoid arthritis: In RA-FLSs, quercetin also inhibited abnormal migration and invasion by upregulating microRNA-146a (miR-146a) and downregulating GATA-binding protein 6 (GATA6), leading to reduced F-actin organization; given that synoviocyte hypermigration and invasiveness drive pannus formation and joint destruction in RA, these findings support a potential anti-invasive effect [25].