Additionally, colchicine has been approved by the FDA for treating other diseases [227,228] and has been shown to possess anti-inflammatory, antioxidant, and anti-apoptotic activities in NaT-induced SAP-ALI via modulating the expression of NF-κB, Nrf2, STAT3, and AKT [201]. The gene discussed is STAT3; the disease is acute respiratory distress syndrome.