Additionally, colchicine has been approved by the FDA for treating other diseases [227,228] and has been shown to possess anti-inflammatory, antioxidant, and anti-apoptotic activities in NaT-induced SAP-ALI via modulating the expression of NF-κB, Nrf2, STAT3, and AKT [201]. This evidence concerns the gene AKT1 and acute respiratory distress syndrome.