These alterations depend on biological sex; in both humans and rodent models, older females demonstrate increased intestinal absorption of conjugated primary BAs via upregulation of Apical Sodium-dependent Bile Acid Transporter (ASBT), resulting in elevated circulating and brain BA levels associated with synaptic loss and cognitive decline, and BA sequestration improves these phenotypes [172]. Here, SLC10A2 is linked to Mental deterioration.