ZNF346 and infection: This pattern indicates that, in the presence of a biotrophic pathogen, HS favors the prioritization of the SA pathway through repression of JA effector signaling (via increased JAZ expression and decreased LOX1/MYC2/jar1), which is consistent with the classical SA–JA antagonism [67,68] and with the need for plants to suppress responses typically directed against necrotrophs when facing a biotrophic infection.