Each component represents a distinct yet complementary biological domain: H for hemoglobin (anemia and oxygen-carrying capacity), A for albumin (nutritional reserve and inflammation), L for lactate dehydrogenase (cellular turnover and tumor burden), L for lymphocyte count (immune competence), M for monocyte count (immunosuppressive activity), O for overall condition measured by the ECOG PS (functional status), U for uric acid (oxidative stress), N for neutrophil count (systemic inflammatory load), and T for thrombocyte count (tumor-associated inflammation and vascular reactivity). This evidence concerns the gene ALB and neoplasm.