Glucose-6-phosphate dehydrogenase (G6PD) is a key regulator of NADPH production; overexpression of G6PD/TKT downstream of NRF2–MYC drives nucleotide biosynthesis and progression in head and neck squamous cell carcinoma (HNSCC) [116]. The gene discussed is G6PD; the disease is head and neck squamous cell carcinoma.