CASP3 and uveal melanoma: Likewise, GEM significantly upregulated Bax and Caspase-3 while downregulating Bcl-2, in line with findings demonstrating that gemcitabine induces apoptotic cell death in uveal melanoma cells by elevating Bax, activating cleaved Caspase-3, and altering Bcl-2 levels and that inhibition of Bcl-2 enhances GEM sensitivity.