Human single-cell data from Wang et al. [17] further indicate that γδ T cells in CRSwNP acquire a memory–effector and cytotoxic profile, with elevated IL7R, GZMB/GZMH/GZMK, NKG7, PRF1, CXCR6, ITGA1, and ITGB1, supporting enhanced tissue residency, cytotoxicity, and chemotactic potential within polyp mucosa. The gene discussed is PRF1; the disease is chronic rhinosinusitis with nasal polyps.