IGHE and Nasal polyposis: Vδ3+ T cells have been shown to facilitate B cell maturation by inducing CD40, CD86, and HLA-DR expression and promoting IgM secretion [58], a mechanism particularly relevant in nasal polyp tissue, where B cells and plasma cells generate local immunoglobulin responses [17,22], including IgE that sensitizes resident mast cells [17,58].