CDKN2A and atherosclerosis: Through the p38MAPK/p16 pathway, quercetin also inhibits macrophage senescence, which acts in a beneficial way in atherosclerosis treatment, improves lipid profiles, lowers dyslipidaemia, and reduces plaque size by 56% in studies using ox-LDL-stimulated macrophages and ApoE knockout mice [112,113].