Furthermore, Kleemann et al. discovered that quercetin has anti-inflammatory, anti-proliferative, and anti-atherosclerotic effects through reducing human CRP expression, decreasing circulating risk factors such as SAA and fibrinogen, preventing atherosclerosis by 40% in ApoE*3Leiden mice, and modulating vascular inflammation and cell proliferation [117]. The gene discussed is APOE; the disease is atherosclerosis.