Of note, E2F-1 cooperates with EZH2 to drive an aggressive ACC transcriptional program and is a recognized predictor of poor prognosis [45]; thus, the enrichment of its binding motif underscores a central role of cell-cycle dysregulation in ACC, while enriched GO terms point to parallel involvement of developmental and structural pathways in tumor progression. This evidence concerns the gene E2F1 and adrenal cortex carcinoma.