Additionally, deletion of Fmr1 in PV+, but not somatostatin-positive (SST+) neurons, resulted in abnormal anxiety and social behaviors, and dysregulated de novo protein synthesis [94]. Analyses of functional and synaptic connectivity have demonstrated decreased excitatory drive onto inhibitory cells, including in the primary somatosensory cortex (S1) [157] and V1 of Fmr1 KO mice [146]. This evidence concerns the gene FMR1 and Anxiety.