TGM2 and neoplasm: Transglutaminase type 2 (TGM2), a member of the transglutaminase (TGs) family of Glu transaminases, catalyzes the deamidation or alternatively transamination of specific Gln residues in proteins and peptides [8], and its overexpression is thought to be associated with advanced tumor stage, distant metastasis, and tumor chemoresistance [9].