At the same time, several genes downregulated in NPRL2−/− cells are also known to be downregulated in lung cancer (FBLN2 [44], LBH [53], AMPH-1 [54]), glioblastoma (ELAVL2 [55]), and liver cancer (IGFBP4 [56]). Here, IGFBP4 is linked to liver cancer.