Causative damage caused by Birt-Hogg-Dube hereditary cancer syndrome is related to folliculin mutations.443 Mutations in NPRL3 and DEPDC5 were found in glioblastoma,47 and DEPDC5 alternations were detected in colorectal cancer.444 NPRL2 has the most recurrent cancer-associated mutations in lung cancer, hepatocellular carcinoma, glioblastoma, and cancers of the ovary, breast, kidney, and colon.76 Additionally, NPRL2 loss has been associated with decreased sensitivity to the chemotherapeutic agent cisplatin.188,445. Here, NPRL2 is linked to hepatocellular carcinoma.