Even if intermittent dosing of rapamycin extends the lifespan of mice and has a milder impact on glucose homeostasis compared to continuous administration, without triggering the glucose intolerance,411 a long-term administration of rapamycin eventually inhibits not only mTORC1 but also mTORC2 and may lead to hepatic insulin resistance.345,504 Acute mTOR inhibition by AZD8055 also leads to insulin resistance and glucose intolerance.505. Here, MTOR is linked to Insulin resistance.