RICTOR amplification leads to a poor prognosis and short survival in patients with squamous cell lung carcinoma.434 RICTOR is also robustly expressed in HER2-amplified breast carcinoma.435 In addition, its upregulation is associated with metastasis and drug resistance in triple-negative breast cancer and promotes the motility and proliferation of glioma cells.436. Here, RICTOR is linked to central nervous system cancer.