In the tumor microenvironment, CLL cells are stimulated by various signals, including the activation of CD40 signaling, which enhances OXPHOS and glycolysis, increases the expression of antiapoptotic proteins, and is associated with venetoclax resistance.458,459 AZD8055, which suppresses both mTORC1 and mTORC2, effectively reduces mitochondrial mass and respiratory activity and downregulates the expression of antiapoptotic proteins induced by CD40 stimulation to alleviate venetoclax resistance. The gene discussed is CD40; the disease is B-cell chronic lymphocytic leukemia.