PIK3CA and cancer: A more advanced generation of TORKIs, such as Torin2, also inhibits the DNA damage-sensing kinases ATM, ATR, and DNA-PK while retaining limited activity against PI3K.502 TORKIs have shown superior ability to sensitize cancer cells to DNA-damaging agents by disrupting DNA damage response pathways and interfering with cell cycle checkpoint control, a capability that rapalogs notably lacking.503