NPRL2 and non-small cell lung carcinoma: Recent studies have demonstrated that restoring NPRL2 expression via cationic lipid nanoparticle-mediated gene delivery in humanized mouse models represents a promising therapeutic strategy.530 Restoration of NPRL2 expression in KRAS/STK11-mutant anti-PD1-resistant NSCLC models induced DNA damage, cell cycle arrest, and apoptosis while also eliciting a robust antitumor immune response.