These mutations are associated with impaired autophagic flux, as indicated by the accumulation of p62 in autophagosomes in approximately half of the biopsy samples.474 A retrospective study of 50 children with GATOR1 variant-related epilepsy revealed that the majority of patients were resistant to antiseizure medications and presented altered brain structures.475 Epilepsy surgery significantly improved seizure outcomes, indicating that surgery might be a more effective therapeutic approach for patients with GATOR1 variants. Here, SQSTM1 is linked to epilepsy.