It is now also possible to evaluate prior assessments on what phenotypes could be caused by variants in candidate genes such as KDM2A. In a recent work by Dhindsa et al., using a machine learning approach based on gene constraint, expression, and many other gene-level annotations, KDM2A was predicted to cause an autosomal-dominant phenotype of developmental delay, developmental epileptic encephalopathy, and autism in the 99.5th percentile or higher for each phenotype individually.38 The gene discussed is KDM2A; the disease is autism.