KDM2A and Neurodevelopmental delay: However, in the case of individual S19, where (1) the de novo origin of the underlying missense variant could not be proven due to the individuals’ adoption at age 2 months and (2) a lack of a KDM2A-associated methylation pattern, a diagnosis of a KDM2A-related NDD is not warranted, and thus, we did not include this individual in the main cohort (see supplemental notes and Table S4).