According to gnomAD, KDM2A is a gene with a significantly reduced number of pLoF as well as missense variants, indicating that there is a selective constraint on both types of variants in the general population that lacks severe, early-onset phenotypes such as developmental delay, intellectual disability, microcephaly, or short stature (LOEUF = 0.06; pLI = 1; o/e for missense variants = 0.49; Z score = 6.9).14 This evidence concerns the gene KDM2A and microcephaly.