SGK1 and Familial prostate cancer: In parallel, LE-4 cells were uniquely characterized by SGK1 (glucocorticoid-induced protein kinase 1) (Fig 2B9), which is upregulated in primary prostate tumors [30], as well as the well-established RNA gene PCAT14 (prostate cancer associated transcript 14, Fig 2B), a biomarker for prostate cancer diagnosis [31] and response to androgen-deprivation therapy [32].