FOXA1 and Familial prostate cancer: Interestingly, the high-confidence candidate genes identified in this study, which are affected by germline variants in prostate cancer, displayed strong enrichment for FOXA1 targets based on ChIP-seq data from non-cancerous LHSAR cells [23], an immortalized prostate epithelial line expressing exogenous AR [74] (FDR = 8.23e-7, Methods and Materials).