We determined the association between LTBi positivity with severity of COVID-19 as well as mRNA expression of immune related genes including those required for MTB as well as SARS-CoV-2 control; IFN-γ, IFN-α, IL-6, IL-10, OAS1, MAVS, SOCS1 and SOCS3 molecules. This evidence concerns the gene IFNG and COVID-19.