TARDBP and amyotrophic lateral sclerosis: One-way ANOVAs revealed that higher C2 FTLD-TDP risk, relative to C1 ALS risk, was associated with higher TDP-43 burden in each FTLD-TDP characteristic region (all FDR adjusted p < .05, Fig 4), controlling for age at death, sex, and inclusion in the prior ALS or FTLD-TDP GWAS.