TARDBP and amyotrophic lateral sclerosis: We then related these cluster SNPs to individual-level clinical and neuropathological traits within a neuropathologically and/or genetically defined sample of ALS and FTLD-TDP cases, including the presence of neuromuscular impairment and/or cognitive-behavioral impairment and the burden of TDP-43 pathology across brain regions, in a well-characterized sample of more than 250 individuals with ALS and/or FTLD-TDP, through the construction of cluster-specific polygenic risk scores (PRS).