Further limiting the sample to C9orf72 cases which can develop ALS, FTLD-TDP, or both, a one-way ANOVA revealed that the C1 ALS PRS was higher in C9orf72 carriers with MND (MND-only or Cog + MND, compared to Cog-only (F(1,104)=[4.2], p = 0.04), while the C2 FTLD-TDP PRS was higher in C9orf72 carriers with cognitive-behavioral impairment (Cog-only or Cog + MND, compared to MND-only; F(1,104)=[8.62], p = 0.004), Fig 3), controlling for last contact age, sex, and inclusion in the prior ALS or FTLD-TDP GWAS, respectively. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.