miR-490* constrains proliferative capacity in glioblastoma by repressing telomere-maintenance genes Telomeric Repeat-binding Factor 2 (TERF2), Tankyrase 2 (TNKS2) and Serine/Threonine-protein kinase, (SMG1), inducing telomere dysfunction and DNA-damage signalling [35]. The gene discussed is AKT1; the disease is glioblastoma.