Genetic studies have previously reported SNPs at chromosome 15q25.1, which includes the nicotinic receptor subunit genes CHRNA5-CHRNA3-CHRNB4 linked to the risk of LC and PAD,22 of which rs56077333 located in CHRNA3 was found to be shared in five traits in our study. The gene discussed is CHRNB4; the disease is laryngotracheoesophageal cleft.