CHRNA5 and laryngotracheoesophageal cleft: Genetic studies have previously reported SNPs at chromosome 15q25.1, which includes the nicotinic receptor subunit genes CHRNA5-CHRNA3-CHRNB4 linked to the risk of LC and PAD,22 of which rs56077333 located in CHRNA3 was found to be shared in five traits in our study.