The relationship between acromegaly and colonic polyps, as well as with papillary thyroid carcinoma, depends primarily on insulin-like growth factor 1; the cribriform-morular subtype of thyroid carcinoma is linked to FAP through different molecular mechanisms, and its association with acromegaly had not been described, thereby opening the possibility of investigating the mechanisms underlying this connection. This evidence concerns the gene IGF1 and acromegaly.